Simultaneous and forced degradation studies for antidepressant analytes require knowledge of chemical, physicochemical and instrumental methods like High Performance Liquid Chromatography (HPLC), High Performance Thin Layer Chromatography (HPTLC) etc. There have been different experimental and empirical approaches reported in the literature for determination of antidepressant analytes where different approximations were applied. One of the most applied approach is HPLC. Therefore, the objective of this study is to review the literature and optimizing methodologies for simultaneous determination of antidepressant analytes. HPLC, alone or in combination with other methods such as mass, Gas Chromatography (GC) has proven to be key methods for identifying compounds.
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