A Simple High Performance Thin Layer Chromatography Method for the Simulateneous Estimation of Ibuprofen and Famotidine in marketed formulation was developed. The Determination was carried on Silica Gel 60 GF254 HPTLC Plates using a Mobile Phase of Toluene: MeOH: Ethyl acetate: Glacial Acetic Acid (5.5:3.2:1:0.3 v/v/v/v). The absorbance of the spots was measured by Densitometry at 271 nm. The Retention Factor (Rf) was found to be 0.71 for Ibuprofen and 0.22 for Famotidine. Ibuprofen and Famotidine showed a linear response in the Concentrarion Range 1000-5000 ng/band and 40-150 ng/band respectively. The Correlation Co-efficient (r2 Value) for Ibuprofen and Famotidine was found to be 0.998 and 0.997 respectively. The result of analysis has been validated statistically and by Recovery Studies. The percentage recoveries obtained for Ibuprofen and Famotidine ranges from 99.26 to 100.61.
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