The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Escitalopram oxalate and Etizolam in combined tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using 0.01 N HCl as solvent. Escitalopram oxalate has absorbance maxima at 238 nm and Etizolam has absorbance maxima at 249 nm in 0.01 N HCl. The method was validated for linearity, precision, accuracy, LOD, LOQ and solution stability. The method was linear in the concentration range of 4-40µg/ml for ESC and 1-32 µg/ml for ETI with a correlation coefficient of 0.9999 and 0.9998 for respective drugs. The percent recovery was found in the range of 98.39-101.13% and 98.07-101.83 % for ESC and ETI, respectively. The proposed method was successfully applied for quantitative determination of Escitalopram oxalate and Etizolam in combined tablet dosage form for routine analysis.
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