In UV Spectrophotometry Method, Methanol use as Solvent and λmax of Amlodipine besylate and Clopidogrel bisulphate selected for analysis were found to be 361nm and 264nm. A simple Reverse phase liquid chromatography method has been also developed and subsequently validated for the tablet dosage form. New UV Spectrophotometric (UV method) have been developed and subsequently validated for the tablet dosage form. The Linear regression equations for Amlodipine Besylate and Clopidogrel bisulphate was found to be 0.019x-0.017, R2 = 0.998 and 0.001x + 0.022, R2 = 0.998 (in µg/ml) measured at 361nm and 264nm respectively in concentration range of 5-25µg/ml and 75-375µg/ml and Recovery studies was found to be 100.05-100.34% for AML and 99.80- 100.25% of CLOP. Other all the data (Precision, LOD and LOQ, Assay, Robustness) are within the specified criteria of ICH guideline.
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