A simple, specific, accurate, precise and reproducible spectrophotometric method has been developed and validated for the simultaneous estimation of Aliskiren Hemifumarate (ALK) and Valsartan in their combined tablet dosage form. Methanol was selected as a common solvent for Aliskiren Hemifumarate and Valsartan for determination at 275 nm and 250 nm over the Linearity range of 30-80 and 5-25 μg/ml respectively. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The suitability of this method for quantitative determination of Aliskiren Hemifumarate and Valsartan was proved by validation and recovery studies. The % recoveries of Aliskiren Hemifumarate and Valsartan were found to be 99.32 -99.89% and 99.12 - 99.71% respectively. Limit of Detection and Quantitation were found to be 4.0749μg/ml and 12.3482μg/ml for Aliskiren hemifumarate and 3.51μg/ml and 10.6551μg/ml for Valsartan. The method was validated as per International Conference on Harmonization (ICH) guideline.
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