A new, precise, accurate and selective TLC-Densitometry method has been developed for simultaneous determination of Tamsulosin Hydrochloride and Finasteride in tablet dosage form. Chromatographic separation was performed on aluminum Precoated with silica gel 60 F254 using Ethyl Acetate: Chloroform: Triethylamine (9.5:1.5:0.15v/v/v) as Mobile Phase. Detection was carried out densitometrically at 279 nm. The Rf values of Tamsulosin Hydrochloride and Finasteride are 0.189±0.02 and 0.344±0.03 respectively. The reliability of method was assessed by evaluation of Linearity which was found to be 400-1360ng per spot for Tamsulosin Hydrochloride and 5000-17000ng per spot for Finasteride. Accuracy of method was assessed by % Recovery which was found to be 99.06-99.82% and 99.59-99.80% for Tamsulosin Hydrochloride and Finasteride respectively. Thus, this method can be used for routine analysis of Tamsulosin hydrochloride and Finasteride in combined tablet dosage form.
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