Present work describes UV Spectrophotometric methods for simultaneous estimation of Tolperisone Hydrochloride (TOL) and Paracetamol (PAR) in tablet dosage form. For simultaneous equation method (method-I) wavelengths selected were 260 nm and 242 nm and in first derivative zero crossing method (method-II) wavelengths were selected 242.20 nm for TOL and 260.30 nm for PAR. In both the methods linearity of TOL and PAR were found to be in concentration range of 3-10 µg/mL and 10-30 µg/mL respectively with correlation coefficient >0.998. Validation of the proposed methods was carried out for its accuracy and precision according to ICH guidelines. Percentage recoveries in method-I was found to be 99.16% (TOL) and 99.64% (PAR) and in method-II it was found to be 99.53% (TOL) and 100.23% (PAR). These methods are simple, accurate, precise and economical. There was no interference of any excipient in the determination of drugs in tablets. These methods can be applied for routine quality control analysis and dissolution study.
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