Hetrocyclic compounds are indispensable structural units for both the chemists and the biochemists. There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. Oxadiazole are the major compounds of heterocyclic nucleus for the development of new drugs and the drugs of oxadiazole were the first effective chemotherapeutic agent to be employed systemically for prevention and cure of bacterial-infection. This review provides an overview of anticancer activity of oxadiazole ring fused with heterocycles as reported over the past decades. Various cell lines used for anticancer activities are PC3, BGC823 and Bcap-37 cell, A431 human epidermoid cells. Oxadiazole ring have been explored in the past years and is still used for future development of new drugs against many more pathological conditions. Oxadiazole is an important pharmacophore in modern drug discovery.
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