A series of novel flavanone incorporated semicarbazide derivatives (Y2a–Y2j) was synthesized and characterized by elemental analyses, 1H NMR, IR and mass spectral studies. All the newly synthesized compounds (Y2a- Y2j) were screened for anti-phlogistic (anti-inflammatory) and anti-nociceptive activities against paw edema method, cotton pellet-induced granuloma, formalin induced paw edema in rats and acetic acid-induced writhing test respectively and compared with the standard drug diclofenac sodium and aspirin and compounds Y2c (o-NO2), Y2f (p-OH), Y2g (p-N(CH3)2) and Y2j (p-OH,-m-(OCH3)) having more anti-inflammatory and analgesic effect as compare to Y2a (p-Chloro), Y2b (o-Chloro), Y2d (m-NO2), Y2e (p-NO2), Y2h and Y2i (o-OH) and antimicrobial activity were also tested for their anti bacterial activity against gram positive bacteria S. aureus and B. antracis while gram negative bacteria P. aeruginosa and E. coli. And same compounds were tested for their anti fungal activity against C. albicans and A. Niger using cup plate method. Streptomycin, erythromycin, fluconazole and ketoconazole were used as a reference compound. The entire compounds shown good activity against gram positive and gram negative bacteria. The compounds Y2a (p-Chloro), Y2b (o-Chloro), Y2d (m-NO2), Y2e (p-NO2), Y2h and Y2i (o-OH) show moderate activity while Y2c (o-NO2), Y2f (p-OH), Y2g (p-N(CH3)2) and Y2j (p-OH,-m-(OCH3)) show good anti fungal and anti bacterial activities.
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