In the present study, Schiff bases of P-toluidine have been synthesized by reaction with different aromatic aldehydes and the Azetidinones have been synthesized by cyclocondensation of the synthesized Schiff’s base with chloroacetyl chloride in the presence of triethylamine. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, Mass Spectroscopic and Elemental analysis. The synthesized compounds were screened for their in vitro growth inhibitory activity against different strains of bacteria and fungi viz., Staphylococcus aureus, Escherichia coli and Aspergillus niger, Candela albicans were compared with the standard such as ciprofloxacin (50 μg/ml) and miconazole (50 μg/ml) by cup plate method. Compounds Id, IIc and IId exhibits highest antibacterial activity and compound Id, IIc and IId showed better antifungal activity.
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