Urolithiasis is affecting 10-12% of the population in industrialized countries. The reoccurrence rate is also high. Ionic strength and activity coefficient are the untouched terms in concern of urolithiasis. In the present study, we evaluated the effect of ionic strength of different urinary electrolytes on CaOx crystallization in vitro. CaOx precipitation was induced by the addition of 0.1M sodium oxalate to artificial urine (n=5) in presence of urinary electrolytes in increasing ionic strength order and in absence of urinary electrolyte (control). The presence of CaOx crystals was evaluated immediately by determining OD at 620 nm, size of crystals and Calcium ion concentration. The results saw inhibitory effect of urinary electrolytes on CaOx crystal growth in artificial urine, suggesting thationic strength may increase the solubility of CaOx crystals by reducing mean molar activity co-efficient, Statistical analysis by comparison of variables of each electrolyte at all levels shows significant difference (P<0.05). Multiple Turkey�s t-test concluded that difference is significant at all ionic strength level (P<0.0001). Electrolyte therapy could be used as an alternative form of treatment. The same can be utilize for the prevention of urolithiasis.
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