Sacral Agenesis which is also known as Caudal Regression Syndrome is a congenital abnormality, which affects the sacrum, the part of spine just above the coccyx. The exact cause of the Sacral Agenesis is not known. An increased incidence of Sacral Agenesis has been associated with maternal diabetes. It is believed that Sacral Agenesis forms during the third to eighth week of foetal development possibly due to some form of toxic or infective damage when this part of the spine is starting to develop. Sacral Agenesis may lead to various symptoms such as urinary incontinence, lower limb deformities. Paediatric population affected with Sacral Agenesis require complex medical care and surgical interventions such as spinal pelvic fusion. Early intervention is important to prevent various complications of Sacral Agenesis.
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