Hypokalemia is one of the most commonly seen electrolyte imbalance in the clinical settings in which the serum potassium levels are less than 3.5 mEq/L (normal range: 3.5 to 5 mEq/L). Hypokalemia usually occurs in conditions such as renal tubular acidosis, villous adenoma of colon, hypomagnesemia, Zollinger Ellison syndrome, cardiovascular disorders, cancer, poisoning and often drug induced. Hypokalemia can be caused by the diuretics, antimicrobials, laxatives, beta 2 receptor agonists, high dose of insulin, xanthines over dose of verapamil, glucocorticoids and mineralocorticoids. In this case report we discussed regarding the management of prednisolone induced hypokalemia condition in a 40 year old female patient who was under the treatment for Pemphigus Vulgaris in the department of dermatology. Hypokalemia is occasionally confronted adverse reaction in the clinical setting where physicians and clinical pharmacists should be attentive while treating the patients. Early diagnosis and treatment may avoid the life threatening complications. As most of the hypokalemia incidences are drug induced, clinical pharmacists who monitor the patient’s drug therapy should be cautious in finding out the etiology of hypokalemia thereby aiding the patient wellness by decreasing the hospital stay and economic burden of the patient.
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