Pantoprazole is the drug of proton pump inhibitor class. It is used for the treatment of stomach ulcers, short-term treatment of heartburn, gastroesophageal reflux disease. An ADR report related to a patient he developed vitamin B12 deficiency while being treated with pantoprazole. The patient, who had been treated with pantoprazole 20 mg BD for stomach upset, vomiting (G.I disturbance). After the treatment of 1 month the patient started weakness, pale skin, tingling in hands, dizziness and fatigue. The patient consulted his physician who is a gastroenterologist. After a thorough examination the physician asked to patient for blood tests which revealed that the Hb is normal but the amount of Vit. B12 present in the blood is less than the normal. It was confirmed that, after the use of pantoprazole Vit. B12 blood levels have decreased which lead to the sign and symptoms. This case report summarizes that on long term use of pantoprazole should be supported by supplemental therapy with Vit. B12.
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