Obesity is nowadays a common and challenging health problem. Its prevalence is on the rise in all age groups in developed countries of throughout world. The exact aetiology of obesity still remains obscure. It is mainly caused by a combination of genetic factors, inappropriate eating and reduced activity. The development and progression of obesity is mainly resides on dysregulation of various hypothalamic mechanisms which controls energy intake and expenditure. Steady advances have been made in understanding the weight regulating mechanisms, which has defined novel targets to reduce intake and increase the expenditure of energy. Based on this, many new antiobesity drugs have been developed. Some of them are in the early stages of development and few of the compounds acting on these sites are already available. Hence, the present review explores on different central and peripheral target strategies of weight reduction employing pharmacological and non pharmacological ways in the treatment and management of obesity.
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