Oxidative stress is an imbalance between the generation of reactive oxygen species and antioxidant defense capacity of the body. Oxidative stress causes cell mitochondrial dysfunction, accumulation of misfolded proteins, inflammation, defects in protein clearance and cell death as a result of disease progression. Oxidative stress is closely related to various disorders such as cancer, diabetes, ageing, atherosclerosis, neurodegenerative disorders like Alzheimer disease, Parkinson’s disease, diseases of eye, respiratory diseases. In addition they also play a role not only in acute conditions, such as trauma, stroke and infection but also in physical exercise and stress. The present review will focus on oxidative stress related diseases and role of various antioxidants in reducing the progression of the diseases.
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