The objective of present study was to evaluate both qualitatively and quantitatively the toxic effect of Cefepime on rat’s kidney and liver via measuring the in vivo concentration of the antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione reductase, creatinine along with malonaldialdehyde (MDA), total bilirubin level and uric acid levels in albino rat. Though some of the cephalosporin has the unique characteristics of scavenging the free radicals, but the observed results showed that the activities of the antioxidant enzymes such as superoxide dismutase, catalase, glutathione reductase were significantly lowered along with increase in the MDA levels after the treatment with amikacin as compared to control group (normal saline). Cefepime has also found to increase other biochemical parameters such as SGOT, SGPT, Uric Acid, Total Bilirubin and Creatinine in the treated group as compared to control group. The results were further supported by the histological reports These findings suggest that the treatment with cephalosporin, such as Cefepime leads to a significant free radical generation which leads to oxidative stress, resulting into a significant hepatic and renal tissue injury.
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