Huntington’s disease is a neurodegenerative disease characterized symptoms like chorea and dementia. 3-Nitropropionic acids, a neurotoxin causes motor impairment in rats. 3- Nitropropionic acid treatment significantly impaired motor movement as assessed in Locomotor activity. The treatment with Vinpocetine (5, 10 & 20mg\kg) significantly improved motor movement. The present study demonstrated that inhibition of type 1 phosphodiestera (PDE1) by vinpocetine significantly improved motor movement following first dose of i.p. 3-NP injection in rats. The result of the present study suggests facilitator role of PDE1 enzyme in motor dysfunction following 3-NP injection.
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