A study was undertaken of the characteristics and Antidiabetic activity of “Melia Azedarach” (Meliaceae) Leaves, native to India, Southern China and Australia; the genus Melia includes four other species, occurring from south East Asia to Northern Australia. Extraction process of Melia Azedarach was carried out by using Ethanol and Limonoids were separated from the ethanolic extract. Furthermore, the phytochemical investigations were performed by using different test and TLC method. An analysis of limonoid was made using column chromatographic, HPLC (High Performance Liquid Chromatography) and FT-IR. Laboratory bioassays were carried out on alloxan induced diabetic rate. Finally, limonoid, flavonoid and sterols containing leaf extracts of M. azedarach were effective in decreasing blood glucose level in alloxan induced diabetic rats.
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