Researchers have recently focused on selective COX-2 inhibitors, which are believed to reduce inflammation without influencing normal physiologic functions by inhibiting only COX-2. In this background we have endeavour to identify new scaffold from zinc database as selective cyclooxygenase 2 inhibitor. The docking analysis revealed that sulfone oxygen of sulphonamide cluster apparantly involved in hydrogen bonding with residues namely His 90, Arg513 while amine site in sulphonamide form hydrogen bond with Leu352 thereby inhibiting the cox 2 in a selective manner. The present analysis is valuable for the future design of novel cox 2 inhibitor.
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