Phosphodiesterases (PDEs) comprise a family of enzymes that modulate the immune response, inflammation, and memory, among many other functions. There are three types of PDEs: cAMP-specific, cGMP-specific, and dual-specific. In order to identify novel lead effective at micromole concentration, we have carried out target search option I zinc database and recognized a lead (zinc_197999526) effective at 1µm (Ki 1 µm). The docking analysis revealed that lead molecule interact with phosphodiesterases enzyme through arene-cation, hydrogen bonding and nonbonding interactions. The present analysis proposes a novel compound zinc_197999526 effective at micromole level and inhibit phosphodiesterases throgh hydrogen bonding and arene-cation interactions. The present analysis may be useful for future drug design.
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