Atenolol is a cardioselective β-blocker widely used in hypertension. Atenolol is poorly absorbed from the lower gastrointestinal tract and the oral bioavailability of atenolol was reported to be 50 %. The short biological half life of drug (6 to 8 h) also favors development of controlled release formulations. The result of the present study demonstrated that the okra gum obtained from the fruit of plant Abelmoschus esculentus is light green coloured powder which is amorphous in nature. Drug release from the prepared tablets was slowed over 12 h and depended on the composition of okra gum. Atenolol release was diffusion controlled and followed zero order kinetics. Non-fickian diffusion was the drug release mechanism from the prepared atenolol controlled release tablets. Therefore Okra gum is an efficient release retarding polymer for controlled release tablets.
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