The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using a combination of super disintegrating agents for enhancing the dissolution rate. Recently Fast Disintegrating Tablets (FDT) have started gaining popularity and acceptance as Novel Drug Delivery Systems (NDDS), because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as a bronchodilator. It forms part of initial therapy of acute as well as chronic asthma. In present work an attempt has been made to formulate and evaluate fast disintegrating tablets of Salbutamol Sulphate. Ac-di-sol (CCS), Polyplasdone–XL (CPV) and Primojel (SSG) were used as super disintegrating agents individually and in combinations of two super disintegrants (CCS: CPV; CCS: SSG and CPV: SSG) in the ratio 1:1 respectively for to study the effect of combination on the physical and dissolution parameters of the, while Mannitol (Pearlitol SD 200) is used as diluent. Direct compression technique was used as it requires conventional tablet machinery and thus process is economical. Formulations containing combination of super disintegrants CCS: CPV in the ratio 1:1 show rapid in-vitro and in-vivo dispersion time and faster dissolution rate as compared to other formulations.
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