Huntington’s disease is a neurodegenerative disease characterized symptoms like chorea and dementia. 3-Nitropropionic acid, a neurotoxin causes memory impairment in rats. 3- Nitropropionic acid treatment significantly impaired memory as assessed in Morris water maze. The treatment with Vinpocetine (5, 10 & 20mg\kg) significantly improved memory. The present study demonstrated that inhibition of type 1 phosphodiestera (PDE1) by vinpocetine significantly improved learning and memory following first dose of i.p. 3-NP injection in rats. The result of the present study suggests facilitatory role of PDE1 enzyme in cognitive dysfuntion following 3-NP injection.
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