Epilepsy is a neurological disorder characterized by seizures and convulsion. The present review is on preclinical evaluation of antiepileptic drugs which includes etiology, epidemiology, pathophysiology, pharmacotherapy involved in epilepsy. The review also includes detail information of various in vitro and in vivo models for screening of plant extract and synthetic antiepileptic drugs. These models reveal purpose and rationale, evaluation, procedure, and probable mechanism of drug action. This also includes various literatures and work done till date on antiepileptic drugs.
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