With the objective of reducing analysis time and maintaining good efficiency, there has been substantial focus on high-speed chromatographic separations. Recently, commercially available ultra-performance liquid chromatography (UPLC) has proven to be one of the most promising developments in the area of fast chromatographic separations. In this work, a new isocratic reverse phase chromatographic method was developed using UPLC for Ziprasidone Hydrochloride Monohydrate. The newly developed method is applicable for assay determination of the Ziprasidone in capsule dosage form. The chromatographic separation of Ziprasidone was achieved on a Zorbax SB C-8 (50 x 4.6) mm, 3.5 µm column within a short runtime of 2 min. The method was validated according to the International Conference on Harmonization [ICH] guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability.
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