The enhancement of oral bioavailability of poorly water soluble drugs is the biggest challenge in the new drug development in recent years. On the basis of recent findings, it is revealed that majority of approved new drugs were water insoluble. However, the release rate is increased by improvement of the solubility through various methods. Out of these methods solid dispersion is the excellent technique for the solubility enhancement and thereby enhances the oral bioavailability. Solid dispersion can be prepared by different methods like solvent evaporation, dropping solution, fusion (melt), hot melt extrusion, lyophilization, spray drying method and many others. The purpose of this review article is to describe the solid dispersion technique for the attainment of effective absorption and improved bioavailability. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier, molecular arrangement of drugs in solid dispersions are discussed in this article. This article also reviews various techniques for evaluation of solid dispersion and explains various applications of the solid dispersion in pharmaceuticals.
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