Nifedipine is calcium channel blocker used in angina pectoris and hypertension. It is insoluble in water and its absorption is dissolution rate limited, its half-life is 2 – 6 hrs. Therefore, it is necessary to improve bioavailability and maintain its therapeutic concentration. The main objective of the study was to enhance the dissolution of nifedipine, a poorly water soluble drug by surface solid dispersion technique using different carriers and to study the effect of each carrier on the in vitro dissolution profile In present work the solid dispersions and physical mixture of Nifedipine were prepared with polyvinily pyrrolidone in different ratios 1:1, 1:3, 1:5, 1:7 and 1:9 to enhance its dissolution rate by using solvent evaporation technique. The obtained solid dispersions were dry, nonsticky and free flowing powder. The solid dispersions were evaluated for dissolution test, Solubility, drug content, and polymer interaction study. Among the prepared solid dispersions (1:7) has shown highest solubility and percent drug release, the X-ray diffraction and DSC also shown amorphous structure of Nifedipine.
Loading....