Human papillomavirus (HPV) is a major cause of cervical cancer, which remains a significant public health burden worldwide. Despite the availability of effective vaccines, uptake among adolescent girls remains suboptimal, especially in low- and middle-income countries. Awareness, attitudes, parental decision-making, sociocultural beliefs, affordability and health-system access can influence vaccination. A systematic review framework was developed in accordance with PRISMA 2020 reporting guidance. The uploaded manuscript described searches of PubMed, Scopus, Web of Science and Google Scholar for English-language studies published from 2010 through 2025. Eligible studies focused on adolescent girls aged 10–19 years and reported awareness, acceptance, or barriers related to HPV vaccination. Because the source draft does not contain an auditable search log or exact screening dataset, the PRISMA counts in this version are presented as provisional rather than as independently verified counts Findings indicate that awareness levels are generally low, acceptance is influenced by knowledge and attitudes and multiple barriers exist at individual, social and systemic levels. Improving education, addressing misconceptions and strengthening healthcare systems are essential to increase vaccine uptake.
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