Background: This observational, prospective, analytical, and cross-sectional study was designed to systematically analyze ocular biometric parameters in patients with nuclear cataract exhibiting nuclear hardness grade ≥ 3 according to the Emery- Little classification under slit-lamp examination who scheduled for phacoemulsification. Ocular biometric measurements were acquired using the IOL Master 700, a sweptsource optical coherence tomography (SS-OCT) device. Results: Age was negatively correlated with axial length (AL), anterior chamber depth (ACD), white-to-white (WTW), and pupil diameter (PD) (rAL = − 0.13, rACD = − 0.26, rWTW = − 0.18, all P < 0.001; rPD = − 0.09, P < 0.01) but positively correlated with total steep keratometry (TKs) (rTKs = 0.13, P < 0.001). AL was negatively correlated with total flat keratometry (TKf ), TKs, and WTW (rTKf = − 0.3, rTKs = − 0.27, rWTW = − 0.18, all P < 0.001) but positively correlated with ACD and PD (rACD = 0.43, rPD = 0.10, all P < 0.001). Men had smaller TK and PD but larger WTW than women. Conclusions: These findings highlight significant sex-related differences in biometric parameters among patients with nuclear cataract, which are closely related to AL and age. Considering variation with these parameters helps personalize surgical plans and prevent complications.
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