Self-emulsifying drug delivery systems are a lipid-based technological approach with immense promise in enhancing the oral bioavailability of poorly water-soluble drugs. The aim of the present study is to develop and characterize self-emulsifying drug delivery systems of Ibuprofen using medium-chain (MCT) and long-chain triglyceride (LCT) oils, Tween 80 and RH-40 as surfactants, and ethanol, polyethylene glycol 400, and propylene glycol as co-surfactants. Twelve formulations have been prepared, with the components and their ratios derived through solubility studies and construction of pseudoternary phase diagrams. All formulations have been characterized through Fourier transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC), thermodynamic stability studies, accelerated stability studies, percent transmittance, droplet size and zeta-potential analysis, and in vitro drug release studies. The results indicate that self-emulsifying drug delivery systems are a promising approach for enhancing the solubility, and the rate and extent of release of Ibuprofen. The advantages of the combination of medium-chain triglycerides and Cremophor RH-40 are evident.
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