The aim of the present study is to develop a delivery system wherein the gastric retention would be achieved for Cefpodoxime which is mainly absorbed in the upper part of the gastrointestinal tract and the unabsorbed fraction, which arrives to the colon in conventional dosage forms, may cause serious local side effects may be avoided. Therefore gastroretentive drug delivery system is an excellent solution to reduce the appearance of such drugs in the colon. Matrixes of different polymer ratio Cefpodoxime were prepared by direct compression method. The major objective of the present investigation was to develop a gastroretentive drug delivery system containing Cefpodoxime using differnt polymer ratio by direct compression technique.\r\nThe drug kinetic release of Cefpodoxime was fitted to different models based on coefficient of correlation (r). All the formulations, except A2, A3 and A6 showed Korsemeyer-Peppas model as the best fit model. Formulation A2 and A3 showed first order model while A6 showed zero order model. Diffusion exponent (n) value was found in the range of 0.52-0.99 indicating diffusion as a release mechanism. The swelling studies of all the formulations showed that formulations containing Xanthan gum has higher swelling indices than HPMC K100M and HPMC K4M. It can be concluded that formulations having higher swelling retarded the release of drugs more than those with lower swelling.
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