To develop formulation for effective management of treatment of various fungal disease caused by Candida species, ketoconazole, a broad-spectrum imidazole antifungal drug with a very short half life (2 hour) coated with Eudragit S 100 and Eudragit RL 100 technique to enhance effective prolong drug release for delivery in stomach. Microspheres with an internal hollow structure were prepared by a Novel quasi emulsion diffusion method and were investigated. Ketoconazole could be coated with Eudragit S 100 and Eudragit RL 100 with an entrapment efficiency of 70.12%. Spherical, transparent and free flowing hollow microspheres were obtained. Scanning electron microscopy revealed the spherical structure under the magnification of 200 �µm. The FTIR and DSC analysis indicated the stability and compability of drug in Eudragit S 100 and Eudragit RL100 microspheres. The microspheres were in the suitable particle size range of 421 to 660�µm. No appreciable difference was observed in the stability study, in the extent of degradation of product for 60 days in the microspheres that were stored at various temperatures. In vitro and in vivo release study showed that ketoconazole release from all formulation was also slow and controlled release.
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