Nowadays, the emphasis of pharmaceutical research is turned towards the development of more efficacious drug delivery systems with already existing molecule rather than going for new drug discovery. In recent years, considerable attention has been focused on the development of pulsatile drug delivery systems [PDDS]. Pulsatile drug delivery system is one of the most interesting time- and site-specific drug delivery system. Pulsatile drug delivery is defined as the rapid and transient releases of drug from the dosage form within short period of time immediately after a predetermined off-release period. Pulsatile drug delivery systems are required for applications in which the continuous release of a drug would be detrimental and repeated dosing would be difficult, painful or otherwise problematic. The conventional sustained release drug delivery had so many problems like first pass metabolism, biological tolerance, gastric irritation etc., which lead to the development of delivery system which overcome all these problems and also provides better local effect and delivers in chronological order. The drug release can be pre-planned or stimuli induced by temperature, chemical or external factors. . It has been recognized that many symptoms and onset of disease occur during specific time periods of the 24 hour day, e.g., asthma and angina pectoris attacks occur most frequently in the morning hours. The pulsatile drug delivery system can release the drug in during specific time periods and thus, better management of these types of diseases can be achieved.
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