The objective of the present study was to formulate a microemulsion system for ocular administration to improve the solubility and bioavailability due to efficient penetration of nano sized globules into the deep tissues of eye. Various formulations were prepared using different ratios of oils, surfactants and co-surfactants (S and CoS). Pseudo-ternary phase diagrams were constructed to evaluate the microemulsification existence area. The formulations were characterized by solubility of the drug in the vehicles, mean droplet size, zeta potential, drug content and in-vitro permeation study. The formulation was optimized using simplex lattice design and the optimal formulation consists of 12% Peceol, 14.66% Soluphor P, 29.34% Labrasol and 44% water (w/w), with a maximum solubility of Moxifloxacin up to ∼14.82 mg/ml. The mean droplet size of optimized microemulsion was 46.50 nm. The in-vitro permeation study result showed that percentage release of moxifloxacin from microemulsion vehicle was 93.72% in 1 hr. Our results indicated that the microemulsions could be used as an effective formulation for improvement in absorption, permeation and hence bioavailability and scale up flexibility.
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