Skin is the largest organ of the body which serves many functions. Because it is protective outermost layer of the body gets affected with environmental and microbial hazards. Some of the skin infections and disorders are difficult to treat and some reoccur because of insufficient treatment. Skin diseases of severe category can be treated by topical as well as systemic treatment using therapeutic agents. Any therapeutic agent given orally or by injection for the treatment of skin diseases will have more side effects than applied topically. This is the origin of this research. Salicylic acid and minocycline HCl are two drugs which are effective in the treatment of acne, dermatitis and fungal infections but failed to penetrate the skin effectively as both belong to BCS class III. Minocycline HCl is still under clinical trial for topical use. So this project was undertaken to design and develop better drug carrier system for these two drugs through skin. Liposomes are usually obvious answer but ethosomes may prove better, so the objectives decided for this study were: design, development and optimization of liposomal drug delivery for these two drugs; design, development and optimization of ethosomal drug delivery for these two drugs and compare liposomes and ethosomes with respect to % entrapment efficiency, vesicles size, skin penetration. During this research the liposomes and ethosomes were put into gel base and compared with marketed topical formulation (for salicylic acid). Since, there is no marketed formulation for minocycline HCl. 2% gel of minocycline HCl was prepared and compared with ethosomal and liposomal gel. In conclusion ethosomal drug delivery proved better than liposomal drug delivery with respect to skin penetration as well as % entrapment efficiency. Thin film hydration method proved better than other methods of liposomes and ethosomes preparation used.
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