Nanoemulsions have received great attention for various applications including, dermal and transdermal drug delivery due to higher storage stability, ease of preparation, lower preparation cost, thermodynamic stability, permeation enhancement activity of their components and a high solubilizing capacity for various drugs over conventional topical formulation vehicles. So the aim of this study was to develop a nanoemulsion for transdermal delivery of lacidipine, as an antihypertensive drug, so as to avoid extensive first pass metabolism. Nanoemulsions containing 1% lacidipine were prepared using capryolTM 90 as oil, cremophor RH 40/ transcutolTM HP in the ratio of 3:1 as surfactant and co-surfactant respectively and assessed for visual inspection, pH measurements and droplet size analysis. In vitro permeation of lacidipine from nanoemulsion formulae through semi-permeable membranes was carried out and compared to lacidipine suspension. In all tested formulae, the permeation of lacidipine was at a higher rate than that from the suspension. N4 showed the highest permeation where 90.52±1.22% of lacidipine was permeated within 24 h.
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