The main aim of present research work was to formulate and evaluate chitosan based superporous hydrogel of simvastatin and to provide controlled release dosage form of by formulating gastric retention device. Simvastatin was chosen as good candidate for such system due to its narrow absorption window, low bioavailability and short half-life. SPHs were prepared by using chitosan and PVA (polymers), glyoxal (crosslinker), sodium bicarbonate (foaming agent), Span 80 (foam stabilizer). GAA and water were used to prepare chitosan and PVA solutions respectively. Direct addition method is used for drug loading. Suitable drug loading method was determined on the basis of drug content and in-vitro dissolution study. Optimized SPHs were evaluated for physical and mechanical properties like swelling ratio, geletion kinetics, density, viscosity, porosity, degradation kinetics, FT-IR spectroscopy, DSC. Direct addition method showed % drug release 95.31% with complete swelling of SPH. Results for optimized batch evaluation were found to be: The swelling ratio 3.70; after 90 min. at pH 1.2, gelation time; 29 sec., density; 0.41±0.003 g/cm3, viscosity; 210.1±4.75 cP, porosity; 89.77±4.83, degradation study; WRt of 0.037after 42 hr. Stability studies were carried out for 3 month as per ICH guidelines. There was no significant change in % drug release and other evaluation parameters. From above studies it can be concluded that the SPH of Simvastatin can be successfully formulated and evaluated.
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