Controlled release local delivery systems offer advantage compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluated sustained release dental implants containing doxycycline hyclate. Doxycycline hyclate (DOX) is an antimicrobial agent that is effective against periodontal pathogens in 100 mg oral dose. Attention has been drawn toward the formulation of DOX in a reduced dose dental implant (0.6 mg / 0.14 cm2) that can support inhibitory concentration of DOX and can be placed into the periodontal pocket for at least one week. Dental implants were prepared by solvent casting technique, using chitosan either alone or co-polymered with; Eudragit L100-55, PVP K30, HPMC-K4M, HPC or HPMC-E4 and glycerin as plasticizers; The dental implants were evaluated for physicochemical and mechanical properties, in-vitro release and anti-microbial activity to determine the optimum formulation. The selected dental implant (F#1 containing both DOX and chitosan 1% W/V) showed good anti-microbiological activity against Staphylococcus aureus and Escherichia coli at this reduced dose. The study suggested that chitosan based dental implant of DOX is a promising delivery system for periodontitis treatment.
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