The aim of this work was to develop a tablet for the buccal delivery of the poorly water-soluble drug carvedilol. Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). HPMC K100 and carbopol were selected as mucoadhesive polymers while ethyl cellulose, as backing material. The complexation was further characterized and studied by FTIR. The mucoadhesive tablets for the delivery of carvedilol were prepared by factorial designs by direct compression of HPMC K100 and carbopol. The tablets were evaluated for their dissolution, surface pH, swelling study and mucoadhesive properties. The surface pH of all formulations was found to be within ±1 units of neutral pH hence these formulations should not cause any irritation in buccal cavity. Carbopol showed superior bioadhesion properties compared to HPMC. The in-vitro release results demonstrated that drug was released by non-fickian diffusion mechanism with first order kinetics. From the drug release data, it was evident that formulation F5 has shown highly satisfactory values for correlation coefficient percentage in-vitro release 0.994, swelling index is 78.4±1.04 (after 6 hours) best formulation with correlation coefficient of 0.994. Hence, formulation F5 may be considered as the optimized buccal tablet containing carvedilol improved bioavailability.
Loading....