Microsponges delivery systems (MDS) composed of tiny sponge like spherical particles that consist of a myriad of interconnecting voids of particle size range 10-25µm within a non collapsible structure with a large porous surface. Microsponge is a versatile drug delivery vehicle and can suspend or entrap a wide variety of substances. The outer surface is typically porous, allowing a sustained flow of substances out of the sphere. It offers numerous advantages over other technologies like reduced side effects, improved stability, increased elegance and enhanced formulation flexibility. Microsponges are porous, polymeric microspheres that are used mostly for topical and recently for oral administration as well as for biopharmaceuticals (peptides, proteins and DNA-based therapeutics) drug delivery. Specifically, microsponges lessen the irritation usually associated with powerful therapeutic agents used topically like retinoids or benzoyl peroxide. They can be incorporated into conventional dosage forms such as creams, lotions, gels, ointment, tablet and powder and share a broad package of benefits & thus provides formulation flexibility. MDS technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. This review article covers methods of preparation, release mechanism, characterization and applications of Microsponge delivery system with patent information and marketed topical formulations.
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