Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non‐aqueous media. Drug nanosuspensions emerged as one promising solution for delivering such poorly soluble drugs. A pharmaceutical nanosuspension is defined as very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, bearing size below 1 µm, without any matrix material, stabilized by surfactants and polymers prepared by suitable methods for drug delivery applications, through various routes of administration like oral, parenteral, ocular and pulmonary routes. Scaling down to nanoparticles enhances drug aqueous solubility, bioavailability and thus therapeutic efficacy by increasing drug surface area that comes into contact with biological media. These are simple to prepare and bear several beneficial aspects intended to improve in-vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and targeted delivery which are discussed in this review. The present review also describes formulation criteria, different preparation methods with their merits and demerits, characterization techniques and achievements of nanosuspension in drug delivery system. Additionally, transformation of nanocrystals to final formulations and future trends of nanocrystals have also been described in this review article.
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