The objective of the present study was to increase the solubility and dissolution rate of poorly soluble drug ritonavir. Ritonavir is having low aqueous solubility and high permeability which can be considered as drug belonging to class-II according to BCS. In this study nanosuspension technology was tailored to increase solubility and dissolution rate of ritonavir and to transfer into dry powder which is suitable for filling into capsules. Ritonavir nanosuspension was prepared by pearl milling technique using zirconium beads as a milling media and poloxamer407 as a stabilizer. The prepared nanosuspension was characterized by particle size analysis, zeta potential, DSC and XRD studies. Ritonavir nanosuspension was dried using vacuum tray drier, the dried mass was filled into capsules by adding polyplasdone XL-10, span-20 and magnesium stearate. The capsules were evaluated for drug release, assay and stability. The nano sized crystalline ritonavir alone and in capsule dosage form showed dramatic increase in solubility and dissolution rate when compared to the micronized ritonavir.
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