This research work was done to design oral controlled release matrix pellets of water insoluble drug Propafenone Hydrochloride (PHC), using blend of sodium alginate (SA) and glyceryl palmito stearate (GPS) as matrix polymers, methyl crystalline cellulose (MCC) as spheronizer enhancer, sodium lauryl sulphate (SLS) as pore forming agent. PHC formulations have been developed by the pellitization technique by drug loaded pellets were further characterize with regard to the drug content, size distribution, and pellets were further characterize by Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy ( FTIR) and X-ray Diffraction study ( XRD ). Stability studies were carried out on the optimized formulation for a period of 90 days at 40 ± 2 oC and 75 ± 5% relative humidity (RH).The drug content was in the range of 92.47 – 97.38 %. The mean particle size of drug loaded pellets was in the range 1035 to 1210 mm. SEM photographs and calculated sphericity factor confirms that the prepared formulations were spherical in nature. The drug loaded pellets were stable, compatible, as confirmed by DSC and FTIR studies. XRD patterns revealed the crystalline nature of pure PHC. Loose surface crystal study indicated that crystalline PHC was observed in all formulation and more clear in formulation F3. Drug release was controlled for more than 24 h and mechanism of drug release followed Fickian diffusion. It can be conclude that F3 is an ideal formulation for once a day administration.
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