The present investigation was carried out to evaluate the ability of Eudragit S-100 based enteric coated capsules to target embelin to small intestine. Embelin mainly shows its anthelmintic activity against tapeworms which are mainly found in small intestine. Embelin was extracted successfully from Embelia ribes burm F. by cold maceration technique. Solid dispersion of embelin with PVP (1:1) was prepared using solvent evaporation method. Since prepared solid dispersion was very fluffy, its granules were prepared in order to improve its flow properties by wet granulation method using isopropyl alcohol as a granulating agent. The prepared granules of solid dispersion were filled in HPMC capsules. Capsules were coated using 3, 5 & 7% w/v Eudragit S-100 aqueous dispersion for 5, 10 & 15% weight gain. Enteric coated capsules were evaluated for various parameters like coating defect, drug content, acid uptake and in vitro drug release. None of the capsule was disintegrated in pH 1.2 within two hours. Since all the capsules remained intact in acidic pH 1.2, it was concluded that enteric coating was achieved successfully. In-vitro dissolution test of enteric coated HPMC capsules showed maximum release of Embelin in phosphate buffer pH 7.4. Thus it was concluded that the formulation E4 (5% Eudragit S-100 with 5% weight gain) is suitable for successful targeting of Embelin to small intestine.
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