This work endeavors at increasing dissolution profile of BCS-II class anti-depressant drug mirtazapine (MIR) by formulating it into self emulsifying drug delivery system. The work involved fabrication of thirty-two formulations using different oils (sesame oil, peanut oil, olive oil and eucalyptus oil), surfactants and co-surfactants (PEG 200, 300 and 400, Span 20 and 80). The formulations were characterized suitably and underwent tests for organoleptic properties, thermodynamic stability, physical nature, physicochemical properties, drug content, dissolution characteristics and accelerated stability studies. Two microemulsion formulations (A6 and A8) were found to be optimized. The optimum formulation (A6) showed cloud point 83±1°C, globule size 266±1.71 nm, viscosity 96.95±1.16 cps, polydispersity index 0.058±0.03 and zeta potential -29.3±2.7 mV. The formulations demonstrated higher dissolution profile (78.22% and 64.41%) than the commercially available tablet formulation (9.47%). Formulation A6 was found to be highly stable and demonstrated no significant changes in accelerated stability studies, which concluded that sesame oil and span 20 are good candidates in preparation of microemulsion. In conclusion, the results suggested that the SEDDS of MIR may be a better dosage form compared to conventional formulations; thereby resulting in enhanced solubility, improved dissolution profile and enhanced patient compliance.
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