The aim of present work is to provide transdermal delivery of acetyl cholinesterase inhibitor provides more beneficial drug delivery over oral drug delivery system. Transdermal patch offer the advantages such as maintenance of controlled and prolong drug level, reduced frequency of dosing, minimization of inter and intrapatient variability, self administration, and easy termination of medication during treatment due to side effects observed leading to patient compliance, directly systemic delivery prevent drug related side effects. Rivastigmine transdermal patch made from different types of pressure sensitive polymers like acrylic adhesive, polyisobutylene adhesive and silicon adhesives. Rivastigmine salt and free base forms were evaluated for In vitro permeation study. Formulations were evaluated for skin permeation study, physical properties. Free base form has significantly higher permeation than salt form. Drug permeation profiles form different PSAs (pressure sensitive adhesives) were evaluated for model dependent release kinetics. It was found that acrylic type PSA formulation has zero order release pattern. PIB (polyisobutylene) and silicone type PSAs indicate peppas model fitting with supercase II type of release pattern. Physical properties of different formulations were evaluated in terms of peel, tack and shear. All formulations were stable during 28 days study and reflects physical stability of formulations. Acrylic type pressure sensitive adhesive has better peel, tack and shear properties. Acrylic pressure sensitive adhesive can be use to prepare stable formulation of rivastigmine with zero order controlled release profile.
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