Pulsatile drug delivery system delivers drug according to circadian behaviour of diseases. This means that these\nsystem deliver drug at time when diseases display it�s most morbid and mortal state within circadian cycle. The objective was to\ndesign and evaluate modified pulsincap of perindopril tert-butylamine according to circadian rhythm using formaldehyde\nvapour for cross-linking to make capsule body water insoluble and hydro gel plug to achieve a predetermined lag time for\nhypertension. The capsule body was made water insoluble by exposing the body to formaldehyde vapour. A physical mixture of\ndrug and excipients was filled in the treated capsule body and hydro gel plug was fitted to the mouth of the treated body and the\nuntreated cap was fitted to the treated body to prevent variable gastric emptying. Developed formulation was evaluated for invitro\ndrug release in pH 1.2 (2 hrs), phosphate buffer pH 6.8 (3 hrs) and phosphate buffer pH 7.4. Formulation F1 showed\npredetermined lag time of 8 hrs. Crosspovidone was used so it was selected as optimized formulation showing the immediate\nrelease of the drug after the lag time of about 8 hrs.
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