The purpose of the present investigation was to formulate gastroretentive floating tablets of venlafaxine\nhydrochloride thus increasing its gastric residence time and therapeutic efficacy. Venlafaxine hydrochloride having a short\nbiological half-life of 4 hrs eliminated quickly from the body leading to low therapeutic efficacy. Therefore a controlled release\nmedication was advantageous so as to achieve the prolonged therapeutic effect. This can be circumvented by formulating\nmodified gastro retentive controlled release dosage forms which resides in the stomach for sufficient time to release the drug.\nVenlafaxine hydrochloride tablets were formulated by direct compression method using polymer HPMC K4M in various\nconcentrations. Sodium bicarbonate and tartaric acid was used as effervescent producing agent. The prepared tablets were\nevaluated for pre and post compression parameters. In-vitro dissolution study was carried out in pH 1.2 buffers. It had been\nfound that increase in polymer concentration diminishes drug release profile. Among the six formulations F5 was best and\nshows 99.18% drug release in the end of 12 hrs.
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