The Mucoadhesive drug delivery system has occupied an important place in the field of\npharmaceutical research. Mucoadhesive tablets prolong the residence time of the drug at the site\nof application and provide extended therapeutic effect. Mucoadhesive tablets have been prepared\nfor various sites thus offering localization as swell as systemic control of drug release. The present\nstudy focuses on the concept of formulation of fluconazole as a mucoadhesive vaginal tablet, for\nimproving the sustained release of drug and localized action of the drug. Different polymers, such\nas Hydoxypropylmethylcellulose M 15, Carbopol71G-NFand Guar Gum were used with different\nconcentrations in order to get the desired sustained release profile over a period of more than12\nhrs. The tablets were prepared by direct compression method. All the formulations were evaluated\nfor crushing strength, friability, swelling behavior, adhesion time, drug content and in vitro drug\nrelease profile. All the formulation tested showed good physical and adhesive properties. It was\nfound that the controlled release rate of the formulation increases with increasing polymer\nconcentration. Kinetican modeling of release data supports an anomalous non-fickian release behavior. The antimycotic activity of selected formulations containing fluconazole (100 mg) was\ndetermined using an agar diffusion technique. Formulations tested showed activity against\nC. albicans.
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